Shopping on line can be easy, simple and save you lots of money. It can also take a lot of your time, frustrate you, and result in unwanted purchases. Now the same can be said for regular high street shopping, but with the vast opportunity presented by the Internet it will pay you to spend a few minutes reading this and understanding how to better optimize your Gastroesophageal Reflux Disease shopping experience:
1. Compare - without doubt the biggest advantage that the Gastroesophageal Reflux Disease offers shoppers today is the ability to compare thousands of Gastroesophageal Reflux Disease at a time. This is a great thing, but not necessarily all the time! Too much can be daunting at times so take advantage of the great comparison sites and where possible let them do the hard work for you.
2. Research - if it has been said it will be on the internet. Ignorance is no longer a justifiable reason for buying the wrong thing. Take the time to research in detail everything that you could possible want to know about
3. Testimonials - don't know anybody that has bought a Gastroesophageal Reflux Disease? Wrong! If the Gastroesophageal Reflux Disease is good the internet will let you know. Use the Internet as a friend and get testimonials before you buy.
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6. Returns - still worried that even after all of the above your Gastroesophageal Reflux Disease wont be what you want? Check out the returns policy. There is so much competition now that someone, somewhere is bound to offer the terms that you are comfortable with.
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9. Contact - got a question about Gastroesophageal Reflux Disease, or want to leave a comment then check out the sites contact page. Reputable companies have them and respond.
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Image = |
Caption = |
DiseasesDB = 23596 |
ICD10 = {{ICD10|K|21||k|20--> |
ICD9 = {{ICD9|530.81--> |
ICDO = |
OMIM = 109350 |
MedlinePlus = |
eMedicineSubj = med |
eMedicineTopic = 857 |
eMedicine_mult = {{eMedicine2|ped|1177--> {{eMedicine2|radio|300--> |
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Gastroesophageal Reflux Disease (
GERD; or
GORD when spelling
œsophageal, the British English form) is defined as chronic symptoms or
mucosal damage produced by the abnormal reflux in the
esophagusDeVault KR, Castell DO. Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease. The Practice Parameters Committee of the American College of Gastroenterology.
Am J Gastroenterol 1999;94:1434-42. PMID 10364004..
This is commonly due to transient or permanent changes in the barrier between the esophagus and the
stomach. This can be due to incompetence of the
lower esophageal sphincter (LES), transient LES relaxation, impaired expulsion of gastric reflux from the esophagus, or a
hiatal hernia.
Symptoms
Adults
Heartburn is the major symptom of acid in the esophagus, characterized by burning discomfort behind the breastbone (
sternum). Findings in GERD include
esophagitis (
reflux esophagitis) — inflammation changes in the esophageal lining (mucosa) —, Stenosis, difficulty swallowing (dysphagia), and chronic
chest pain. Patients may have only one of those findings. Typical GERD symptoms include cough, hoarseness, voice changes, chronic ear ache, burning chest pains, nausea or
sinusitis. GERD complications include stricture formation, Barrett's esophagus, esophageal ulcers, and possibly even lead to
esophageal cancer, especially in adults over 60 years old.
Occasional heartburn is common but does not necessarily mean one has GERD. Patients with heartburn symptoms more than once a week are at risk of developing GERD. A hiatal hernia is usually
asymptomatic, but the presence of a hiatal hernia is a risk factor for developing GERD.
Children
GERD may be difficult to detect in
infants and
children. Symptoms may vary from typical adult symptoms. GERD in children may cause repeated vomiting, effortless spitting up, coughing, and other respiratory problems. Inconsolable crying, failure to gain adequate weight, refusing food, bad breath, and belching or burping are also common. Children may have one symptom or many — no single symptom is universal in all children with GERD.
It is estimated that of the approximately 8 million babies born in the U.S. each year, up to 35% of them may have difficulties with reflux in the first few months of their life. Most of those children will outgrow their reflux by their first birthday. However, a small but significant number of them will not outgrow the condition.
Babies' immature digestive systems are usually the cause, and most infants stop having acid reflux by the time they reach their first birthday. Some children do not outgrow acid reflux, however, and continue to have it into their teen years. Children that have had heartburn that does not seem to go away, or any other GERD symptoms for a while, should talk to their parents and visit their doctor.
Diagnosis
image of peptic stricture, or narrowing of the esophagus near the junction with the
stomach. This is a complication of chronic gastroesophageal reflux disease, and can be a cause of
dysphagia or difficulty swallowing
A detailed history taking is vital to the diagnosis. Useful investigations may include
barium swallow
X-rays, esophageal manometry, 24 hour esophageal pH monitoring and Esophagogastroduodenoscopy (EGD). In general, an EGD is done when the patient does not respond well to treatment, or has alarm symptoms including: dysphagia, anemia, blood in the stool (detected chemically), asthma, weight loss, or voice changes. Some physicians advocate once-in-a-lifetime endoscopy for patients with longstanding GERD, to evaluate the possible presence of Barrett's esophagus, a precursor lesion for esophageal cancer.
Esophagogastroduodenoscopy (EGD) (a form of endoscopy) involves insertion of a thin scope through the mouth and throat into the esophagus and stomach (often while the patient is sedated) in order to assess the internal surfaces of the esophagus, stomach, and
duodenum.
Biopsy can be performed during gastroscopy and these may show:
- Edema and basal hyperplasia (non-specific inflammatory changes)
- Lymphocytic inflammation (non-specific)
- Neutrophilic inflammation (usually due to reflux or Helicobacter gastritis)
- Eosinophilic inflammation (usually due to reflux)
- Goblet cell intestinal metaplasia or Barretts esophagus.
- Elongation of the papillae
- Thinning of the squamous cell layer
- Dysplasia or pre-cancer.
- Carcinoma.
Pathophysiology
GERD is caused by a failure of the Anti-Reflux Barrier (ARB) and its primary component, the GastroEsophageal valve (GEV). The understanding of the GEV has continued to progress in recent years, and more focus is currently being placed on the GEV, rather than the Lower Esophageal Sphincter (LES), as the largest contributor to the ARB. Researchers have shown the GEV's robust nature and have shown that the intact GEV alone is highly competent to stop reflux. For example, in cadavers, where no muscle tone or LES pressure is present, the stomach ruptures when filled with water before reflux can occur. This shows the GEV's power to stop reflux even in the absence of any LES pressure.
In healthy patients, the "Angle of His," the angle at which the esophagus enters the stomach, is intact creating a valve that prevents duodenal bile, enzymes, and stomach acid from traveling back into the esophagus where it can cause burning and inflammation of sensitive esophageal tissue.
Another paradoxical cause of GERD-like symptoms is not enough stomach acid (
hypochlorhydria). The valve that empties the stomach into the intestines is triggered by acidity. If there is not enough acid, this valve does not open and the stomach contents are churned up into the esophagus. However, there is still enough acidity to irritate the esophagus.
Factors that can contribute to GERD are:
- Hiatus hernia, which increases the likelihood of GERD due to mechanical and motility factors
- Obesity: increasing body mass index is associated with more severe GERD
- Zollinger-Ellison syndrome, which can be present with increased gastric acidity due to gastrin production
- Hypercalcemia, which can increase gastrin production, leading to increased acidity
- Scleroderma and systemic sclerosis, which can feature esophageal dysmotility
GERD has been linked to laryngitis, chronic cough, pulmonary fibrosis,
earache, and asthma, even when not clinically apparent, as well as to
laryngopharyngeal reflux and ulcers of the vocal cords. There appears to be an association with
sleep apnea, although its conjectural relationship with GERD remains unproven. and PMID 17198758.
Treatment
The rubric "lifestyle modifications" is the term physicians use when recommending non-drug GERD treatments. A 2006 review suggested that evidence for most dietary interventions is anecdotal; only weight loss and elevating the head of the bed were supported by evidence. A subsequent randomized crossover study showed benefit by avoiding eating two hours before bed.
Foods
Certain foods and lifestyle are considered to promote gastroesophageal reflux:
- Coffee, alcoholic beverage, and excessive amounts of Vitamin C supplements stimulate gastric acid secretion. Taking these before bedtime especially can cause evening reflux. (Although a study published in 2006 by Stanford University researchers disputes the effect of coffee, acidic, spicy foods etc. as a myth.)
- Antacids based on calcium carbonate (but not aluminum hydroxide) were found to actually increase the acidity of the stomach. However, all antacids reduced acidity in the lower esophagus, so the net effect on GERD symptoms may still be positive.Decktor DL, Robinson M, Maton PN, Lanza FL, Gottlieb S. Effects of Aluminum/Magnesium Hydroxide and Calcium Carbonate on Esophageal and Gastric pH in Subjects with Heartburn. Am J Ther 1995;2:546-552. PMID 11854825..
- Foods high in fats and tobacco smoking reduce lower esophageal sphincter competence, so avoiding these tends to help. Fat also delays stomach emptying.
- Eating shortly before bedtime (For clinical purposes, this usually means 2-3 hours before going to bed).
- Large meals. Having more but smaller meals reduces GERD risk, as it means there is less food in the stomach at any one time.
- Soda or pop (regular or diet).
- Chocolate and peppermint.
- Acidic foods, such as oranges and tomatoes
- Cruciferous vegetables: onions, cabbage, cauliflower, broccoli, spinach, brussel sprouts
- Milk and milk-based products contain calcium and fat, and should be avoided before bedtime.
Positional therapy
Sleeping on one's left side has been shown to drastically reduce nighttime reflux episodes in patients.Khoury RM, Camacho-Lobato L, Katz PO, Mohiuddin MA, Castell DO. Influence of spontaneous sleep positions on nighttime recumbent reflux in patients with gastroesophageal reflux disease.
Am J Gastroenterol 1999;94:2069-73. PMID 10445529..
Elevating the head of the bed is also effective. When combining drug therapy, food avoidance before bedtime, and elevation of the head of the bed, over 95% of patients will have complete relief. Additional conservative measures may be considered if there is incomplete relief. Another approach is to apply all conservative measures for maximum response. A
meta-analysis suggested that elevating the head of bed is an effective therapy, although this conclusion was only supported by nonrandomized studies .
Elevating the head of the bed can be done by using various items: plastic or wooden bed risers that support bed posts or legs, a bed wedge pillow, or a wedge or an inflatable mattress lifter that fits in between mattress and box spring. The height of the elevation is critical and must be at least 6 to 8 inches (15 to 20 cm) in order to be at least minimally effective to prevent the backflow of gastric fluids. It should be noted that some innerspring mattresses do not work well when inclined and tend to cause back pain, thus foam based mattresses are to be preferred. Moreover, some use higher degrees of incline than provided by the commonly suggested 6 to 8 inches (15 to 20 cm) and claim greater success.
Drug treatment
A number of drugs are registered for GERD treatment, and they are among the most-often-prescribed forms of medication in most Western countries. They can be used in combination with other drugs, although some antacids can interfere with the function of other drugs:
- Proton pump inhibitors are the most effective in reducing gastric acid secretion. These drugs stop acid secretion at the source of acid production, i.e., the proton pump.
- Antacids before meals or symptomatically after symptoms begin can reduce gastric acidity (increase pH).
- Alginic acid (Gaviscon) may coat the mucosa as well as increase pH and decrease reflux. A meta-analysis of randomized controlled trials suggests alginic acid may be the most effective of non-prescription treatments with a number needed to treat of 4 .
- Gastric H2 antagonist such as ranitidine or famotidine can reduce gastric secretion of acid. These drugs are technically antihistamines. They relieve complaints in about 50% of all GERD patients. Compared to placebo (which also is associated with symptom improvement), they have a number needed to treat of eight (8) ..
- Prokinetics strengthen the LES and speed up gastric emptying. Cisapride, a member of this class, was withdrawn from the market for causing Long QT syndrome.
- Sucralfate (Carafate®) is also useful as an adjunct in helping to heal and prevent esophageal damage caused by GERD, however it must be taken several times daily and at least two (2) hours apart from meals and medications.
Posture and GERD
In adults, a slouched posture is an important factor contributing to GERD. With a slouched posture there is no straight path between the stomach and esophagus; muscles around the esophagus go into a spasm. Gas and acidity get blocked in the spasm, causing coughing and other asthma-like symptoms. A
meta-analysis suggested that elevating the head of the bed is an effective therapy, although this conclusion was only supported by nonrandomized studies.
Surgical treatment
The standard surgical treatment, sometimes preferred over longtime use of medication, is the
Nissen fundoplication. The upper part of the stomach is wrapped around the LES to strengthen the sphincter and prevent acid reflux and to repair a hiatal hernia. The procedure is often done
Laparoscopic surgery.
An obsolete treatment is
vagotomy ("highly selective vagotomy"), the surgical removal of
vagus nerve branches that innervate the stomach lining. This treatment has been largely replaced by medication.
Endoluminal fundoplication
In June 2006 EndoGastric Solutions introduced EsophyX ELF in the Europe Union as an alternative to surgical and pharmaceutical approaches for GERD treatment. EsophyX ELF is intended to deliver similar benefits as the time-proven laparoscopic fundoplication procedures, by reducing hiatal hernia, recreating the Angle of His, and creating a GastroEsophageal Valve (GEV). The key differences are that EsophyX ELF is an endoscopic non-invasive procedure that is performed transorally (through the mouth), does not require incisions, and does not dissect any part of the natural anatomy.
Previous endoluminal treatments focused predominantly on the LES. However, failure to effectively treat reflux long-term with endoluminal therapies that focused only on the Lower Esophageal Sphincter (LES) combined with the fact that surgical approaches like Nissen fundoplication recreate the GEV and have excellent long-term efficacy, has led to an awareness that the GEV is probably the most powerful component of the Anti-Reflux Barrier. The device has been designed to deploy multiple tissue fasteners to create a robust and durable valve and is intended to restore the geometry of the GastroEsophageal Junction and recreate the natural, unidirectional valve mechanism necessary to prevent GERD. EsophyX ELF has recently been cleared by the US FDA and is now available in the U.S.
Other treatments
In 2000 , the U.S.
Food and Drug Administration (FDA) approved two endoscopy devices to treat chronic heartburn. One system, Endocinch, puts stitches in the LES to create little pleats that help strengthen the muscle. Another, the
stretta procedure, uses electrodes to apply radio frequency energy to the LES. The long term outcomes of both procedures compared to a Nissen fundoplication are still being determined.
Subsequently the NDO Surgical Plicator was FDA cleared for the endoscopic GERD treatment. The Plicator creates a plication, or fold, of tissue near the gastroesophageal junction, and fixates the plication with a suture-based implant. The Plicator is currently marketed by NDO Surgical, Inc. .
Another treatment that involved injection of a solution during endoscopy into the lower esophageal wall was available for about one year ending in late 2005. It was marketed under the name Enteryx. It was removed from the market due to several reports of complications from misplaced injections.
Barrett's esophagus
Barrett's esophagus, a type of
dysplasia, is a precursor high-grade dysplasia, which is in turn a precursor condition for carcinoma. The risk of progression from Barrett's to dysplasia is uncertain but is estimated to include 0.1% to 0.5% of cases, and has probably been exaggerated in the past. Due to the risk of chronic heartburn progressing to Barrett's, EGD every 5 years is recommended for patients with chronic heartburn, or who take drugs for chronic GERD.
References
External links
- GERD patient information page at NIH
- KidsHealth GERD Information for Kids
- Mayo Clinic review of diagnosis and treatment options
- Overview at Cleveland Clinic
{{Infobox_Disease | Name = {{PAGENAME--> |
Image = |
Caption = |
DiseasesDB = 23596 |
ICD10 = {{ICD10|K|21||k|20--> |
ICD9 = {{ICD9|530.81--> |
ICDO = |
OMIM = 109350 |
MedlinePlus = |
eMedicineSubj = med |
eMedicineTopic = 857 |
eMedicine_mult = {{eMedicine2|ped|1177--> {{eMedicine2|radio|300--> |
MeshID = D005764 |
-->
Gastroesophageal Reflux Disease (
GERD; or
GORD when spelling
œsophageal, the
British English form) is defined as chronic symptoms or
mucosal damage produced by the abnormal reflux in the
esophagusDeVault KR, Castell DO. Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease. The Practice Parameters Committee of the American College of Gastroenterology.
Am J Gastroenterol 1999;94:1434-42. PMID 10364004..
This is commonly due to transient or permanent changes in the barrier between the esophagus and the stomach. This can be due to incompetence of the
lower esophageal sphincter (LES), transient LES relaxation, impaired expulsion of gastric reflux from the esophagus, or a hiatal hernia.
Symptoms
Adults
Heartburn is the major symptom of acid in the esophagus, characterized by burning discomfort behind the breastbone (sternum). Findings in GERD include
esophagitis (
reflux esophagitis) — inflammation changes in the esophageal lining (mucosa) —,
Stenosis, difficulty swallowing (dysphagia), and chronic
chest pain. Patients may have only one of those findings. Typical GERD symptoms include cough, hoarseness, voice changes, chronic ear ache, burning chest pains, nausea or
sinusitis. GERD complications include stricture formation, Barrett's esophagus,
esophageal ulcers, and possibly even lead to
esophageal cancer, especially in adults over 60 years old.
Occasional heartburn is common but does not necessarily mean one has GERD. Patients with heartburn symptoms more than once a week are at risk of developing GERD. A hiatal hernia is usually
asymptomatic, but the presence of a hiatal hernia is a risk factor for developing GERD.
Children
GERD may be difficult to detect in infants and
children. Symptoms may vary from typical adult symptoms. GERD in children may cause repeated vomiting, effortless spitting up,
coughing, and other respiratory problems. Inconsolable crying, failure to gain adequate weight, refusing food, bad breath, and belching or burping are also common. Children may have one symptom or many — no single symptom is universal in all children with GERD.
It is estimated that of the approximately 8 million babies born in the U.S. each year, up to 35% of them may have difficulties with reflux in the first few months of their life. Most of those children will outgrow their reflux by their first birthday. However, a small but significant number of them will not outgrow the condition.
Babies' immature digestive systems are usually the cause, and most infants stop having acid reflux by the time they reach their first birthday. Some children do not outgrow acid reflux, however, and continue to have it into their teen years. Children that have had heartburn that does not seem to go away, or any other GERD symptoms for a while, should talk to their parents and visit their doctor.
Diagnosis
image of peptic stricture, or narrowing of the
esophagus near the junction with the
stomach. This is a complication of chronic gastroesophageal reflux disease, and can be a cause of
dysphagia or difficulty swallowing
A detailed history taking is vital to the diagnosis. Useful investigations may include
barium swallow X-rays, esophageal manometry, 24 hour esophageal pH monitoring and
Esophagogastroduodenoscopy (EGD). In general, an EGD is done when the patient does not respond well to treatment, or has alarm symptoms including: dysphagia, anemia, blood in the stool (detected chemically), asthma, weight loss, or voice changes. Some physicians advocate once-in-a-lifetime endoscopy for patients with longstanding GERD, to evaluate the possible presence of
Barrett's esophagus, a precursor lesion for
esophageal cancer.
Esophagogastroduodenoscopy (EGD) (a form of endoscopy) involves insertion of a thin scope through the mouth and throat into the esophagus and stomach (often while the patient is sedated) in order to assess the internal surfaces of the esophagus, stomach, and duodenum.
Biopsy can be performed during gastroscopy and these may show:
- Edema and basal hyperplasia (non-specific inflammatory changes)
- Lymphocytic inflammation (non-specific)
- Neutrophilic inflammation (usually due to reflux or Helicobacter gastritis)
- Eosinophilic inflammation (usually due to reflux)
- Goblet cell intestinal metaplasia or Barretts esophagus.
- Elongation of the papillae
- Thinning of the squamous cell layer
- Dysplasia or pre-cancer.
- Carcinoma.
Pathophysiology
GERD is caused by a failure of the Anti-Reflux Barrier (ARB) and its primary component, the GastroEsophageal valve (GEV). The understanding of the GEV has continued to progress in recent years, and more focus is currently being placed on the GEV, rather than the Lower Esophageal Sphincter (LES), as the largest contributor to the ARB. Researchers have shown the GEV's robust nature and have shown that the intact GEV alone is highly competent to stop reflux. For example, in cadavers, where no muscle tone or LES pressure is present, the stomach ruptures when filled with water before reflux can occur. This shows the GEV's power to stop reflux even in the absence of any LES pressure.
In healthy patients, the "Angle of His," the angle at which the esophagus enters the stomach, is intact creating a valve that prevents duodenal bile, enzymes, and stomach acid from traveling back into the esophagus where it can cause burning and inflammation of sensitive esophageal tissue.
Another paradoxical cause of GERD-like symptoms is not enough stomach acid (
hypochlorhydria). The valve that empties the stomach into the intestines is triggered by acidity. If there is not enough acid, this valve does not open and the stomach contents are churned up into the esophagus. However, there is still enough acidity to irritate the esophagus.
Factors that can contribute to GERD are:
- Hiatus hernia, which increases the likelihood of GERD due to mechanical and motility factors
- Obesity: increasing body mass index is associated with more severe GERD
- Zollinger-Ellison syndrome, which can be present with increased gastric acidity due to gastrin production
- Hypercalcemia, which can increase gastrin production, leading to increased acidity
- Scleroderma and systemic sclerosis, which can feature esophageal dysmotility
GERD has been linked to laryngitis, chronic cough, pulmonary fibrosis,
earache, and asthma, even when not clinically apparent, as well as to laryngopharyngeal reflux and ulcers of the vocal cords. There appears to be an association with sleep apnea, although its conjectural relationship with GERD remains unproven. and PMID 17198758.
Treatment
The rubric "lifestyle modifications" is the term physicians use when recommending non-drug GERD treatments. A 2006 review suggested that evidence for most dietary interventions is anecdotal; only
weight loss and elevating the head of the bed were supported by evidence. A subsequent randomized crossover study showed benefit by avoiding eating two hours before bed.
Foods
Certain foods and lifestyle are considered to promote gastroesophageal reflux:
- Coffee, alcoholic beverage, and excessive amounts of Vitamin C supplements stimulate gastric acid secretion. Taking these before bedtime especially can cause evening reflux. (Although a study published in 2006 by Stanford University researchers disputes the effect of coffee, acidic, spicy foods etc. as a myth.)
- Antacids based on calcium carbonate (but not aluminum hydroxide) were found to actually increase the acidity of the stomach. However, all antacids reduced acidity in the lower esophagus, so the net effect on GERD symptoms may still be positive.Decktor DL, Robinson M, Maton PN, Lanza FL, Gottlieb S. Effects of Aluminum/Magnesium Hydroxide and Calcium Carbonate on Esophageal and Gastric pH in Subjects with Heartburn. Am J Ther 1995;2:546-552. PMID 11854825..
- Foods high in fats and tobacco smoking reduce lower esophageal sphincter competence, so avoiding these tends to help. Fat also delays stomach emptying.
- Eating shortly before bedtime (For clinical purposes, this usually means 2-3 hours before going to bed).
- Large meals. Having more but smaller meals reduces GERD risk, as it means there is less food in the stomach at any one time.
- Soda or pop (regular or diet).
- Chocolate and peppermint.
- Acidic foods, such as oranges and tomatoes
- Cruciferous vegetables: onions, cabbage, cauliflower, broccoli, spinach, brussel sprouts
- Milk and milk-based products contain calcium and fat, and should be avoided before bedtime.
Positional therapy
Sleeping on one's left side has been shown to drastically reduce nighttime reflux episodes in patients.Khoury RM, Camacho-Lobato L, Katz PO, Mohiuddin MA, Castell DO. Influence of spontaneous sleep positions on nighttime recumbent reflux in patients with gastroesophageal reflux disease.
Am J Gastroenterol 1999;94:2069-73. PMID 10445529..
Elevating the head of the bed is also effective. When combining drug therapy, food avoidance before bedtime, and elevation of the head of the bed, over 95% of patients will have complete relief. Additional conservative measures may be considered if there is incomplete relief. Another approach is to apply all conservative measures for maximum response. A meta-analysis suggested that elevating the head of bed is an effective therapy, although this conclusion was only supported by nonrandomized studies .
Elevating the head of the bed can be done by using various items: plastic or wooden bed risers that support bed posts or legs, a bed wedge pillow, or a wedge or an inflatable mattress lifter that fits in between mattress and box spring. The height of the elevation is critical and must be at least 6 to 8 inches (15 to 20 cm) in order to be at least minimally effective to prevent the backflow of gastric fluids. It should be noted that some innerspring mattresses do not work well when inclined and tend to cause back pain, thus foam based mattresses are to be preferred. Moreover, some use higher degrees of incline than provided by the commonly suggested 6 to 8 inches (15 to 20 cm) and claim greater success.
Drug treatment
A number of drugs are registered for GERD treatment, and they are among the most-often-prescribed forms of
medication in most Western countries. They can be used in combination with other drugs, although some antacids can interfere with the function of other drugs:
- Proton pump inhibitors are the most effective in reducing gastric acid secretion. These drugs stop acid secretion at the source of acid production, i.e., the proton pump.
- Antacids before meals or symptomatically after symptoms begin can reduce gastric acidity (increase pH).
- Alginic acid (Gaviscon) may coat the mucosa as well as increase pH and decrease reflux. A meta-analysis of randomized controlled trials suggests alginic acid may be the most effective of non-prescription treatments with a number needed to treat of 4 .
- Gastric H2 antagonist such as ranitidine or famotidine can reduce gastric secretion of acid. These drugs are technically antihistamines. They relieve complaints in about 50% of all GERD patients. Compared to placebo (which also is associated with symptom improvement), they have a number needed to treat of eight (8) ..
- Prokinetics strengthen the LES and speed up gastric emptying. Cisapride, a member of this class, was withdrawn from the market for causing Long QT syndrome.
- Sucralfate (Carafate®) is also useful as an adjunct in helping to heal and prevent esophageal damage caused by GERD, however it must be taken several times daily and at least two (2) hours apart from meals and medications.
Posture and GERD
In adults, a slouched posture is an important factor contributing to GERD. With a slouched posture there is no straight path between the stomach and esophagus; muscles around the esophagus go into a spasm. Gas and acidity get blocked in the spasm, causing coughing and other asthma-like symptoms. A
meta-analysis suggested that elevating the head of the bed is an effective therapy, although this conclusion was only supported by nonrandomized studies.
Surgical treatment
The standard surgical treatment, sometimes preferred over longtime use of medication, is the
Nissen fundoplication. The upper part of the stomach is wrapped around the LES to strengthen the sphincter and prevent acid reflux and to repair a hiatal hernia. The procedure is often done Laparoscopic surgery.
An obsolete treatment is
vagotomy ("highly selective vagotomy"), the surgical removal of
vagus nerve branches that innervate the stomach lining. This treatment has been largely replaced by medication.
Endoluminal fundoplication
In June 2006 EndoGastric Solutions introduced EsophyX ELF in the Europe Union as an alternative to surgical and pharmaceutical approaches for GERD treatment. EsophyX ELF is intended to deliver similar benefits as the time-proven laparoscopic fundoplication procedures, by reducing hiatal hernia, recreating the Angle of His, and creating a GastroEsophageal Valve (GEV). The key differences are that EsophyX ELF is an endoscopic non-invasive procedure that is performed transorally (through the mouth), does not require incisions, and does not dissect any part of the natural anatomy.
Previous endoluminal treatments focused predominantly on the LES. However, failure to effectively treat reflux long-term with endoluminal therapies that focused only on the Lower Esophageal Sphincter (LES) combined with the fact that surgical approaches like Nissen fundoplication recreate the GEV and have excellent long-term efficacy, has led to an awareness that the GEV is probably the most powerful component of the Anti-Reflux Barrier. The device has been designed to deploy multiple tissue fasteners to create a robust and durable valve and is intended to restore the geometry of the GastroEsophageal Junction and recreate the natural, unidirectional valve mechanism necessary to prevent GERD. EsophyX ELF has recently been cleared by the US FDA and is now available in the U.S.
Other treatments
In 2000 , the U.S. Food and Drug Administration (FDA) approved two
endoscopy devices to treat chronic heartburn. One system, Endocinch, puts stitches in the LES to create little pleats that help strengthen the muscle. Another, the
stretta procedure, uses electrodes to apply radio frequency energy to the LES. The long term outcomes of both procedures compared to a Nissen fundoplication are still being determined.
Subsequently the NDO Surgical Plicator was FDA cleared for the endoscopic GERD treatment. The Plicator creates a plication, or fold, of tissue near the gastroesophageal junction, and fixates the plication with a suture-based implant. The Plicator is currently marketed by NDO Surgical, Inc. .
Another treatment that involved injection of a solution during endoscopy into the lower esophageal wall was available for about one year ending in late 2005. It was marketed under the name Enteryx. It was removed from the market due to several reports of complications from misplaced injections.
Barrett's esophagus
Barrett's esophagus, a type of
dysplasia, is a precursor high-grade dysplasia, which is in turn a precursor condition for carcinoma. The risk of progression from Barrett's to dysplasia is uncertain but is estimated to include 0.1% to 0.5% of cases, and has probably been exaggerated in the past. Due to the risk of chronic heartburn progressing to Barrett's, EGD every 5 years is recommended for patients with chronic heartburn, or who take drugs for chronic GERD.
References
External links
- GERD patient information page at NIH
- KidsHealth GERD Information for Kids
- Mayo Clinic review of diagnosis and treatment options
- Overview at Cleveland Clinic
Gastroesophageal reflux disease - Wikipedia, the free encyclopedia
Gastroesophageal reflux disease (American English and Canadian English) or Gastro-oesophageal reflux disease (British English, Hiberno-English, Australian English, New Zealand ...
Gastroesophageal reflux disease - Overview - Introduction
Gastro-oesophageal reflux disease (GORD) occurs when stomach acid leaks back up into the oesophagus. This is known as acid reflux. The oesophagus is the tube that runs from your ...
Gastroesophageal Reflux Disease (GERD)
When symptoms of heartburn or acid indigestion are frequent or can't be attributed to spicy ingredients, it could be gastroesophageal reflux disease (GERD). And it can be a problem ...
GERD (Gastroesophageal Reflux Disease, Acid Reflux, Heartburn) Causes ...
Learn about gastroesophageal reflux disease (GERD, acid reflux, heartburn) symptoms like heartburn, chest pain, regurgitation, and nausea. Causes, diagnosis, treatment and ...
MedlinePlus Medical Encyclopedia: Gastroesophageal reflux disease
Alternative Names Return to top. Peptic esophagitis; Reflux esophagitis; GERD; Heartburn - chronic. Definition Return to top. Gastroesophageal reflux disease (GERD) is a ...
Patient Education Tutorials: GERD
Accessibility Notice: The interactive multimedia tutorial is accessible without a screen-reader. The Text Summary is screen-reader accessible.
Gastro-oesophageal reflux disease Introduction - Health encyclopaedia ...
Acid reflux that causes indigestion and heartburn ... What is GORD? Gastro-oesophageal reflux disease (GORD) occurs when stomach acid leaks back up into the oesophagus.
Gastroesophageal Reflux Disease
Answers to your questions about gastroesophageal reflux disease and more! Information you can trust: patient guides, the latest news, tips, tools, animations and newsletters.
Gastroesophageal Reflux Disease | GERD Resource Center | Medscape
Gastroesophageal reflux disease (GERD) is often referred to as reflux or acid reflux and commonly presents as chronic heartburn. GERD affects a significant percentage of the US ...
eMedicine - Gastroesophageal Reflux Disease : Article by Piero Marco ...
Dr. Marco Patti offers a medical review of GERD and its symptoms such as heartburn, cough, and laryngitis.